A highly efficient system for amber suppression

In Jason Chin’s lab, we have developed an efficient system to incorporate unnatural amino acids in mammalian cells. Read more here:

http://pubs.acs.org/doi/abs/10.1021/ja5069728 Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1,

Publications using our system to address novel applications:

http://pubs.acs.org/doi/abs/10.1021/ja512838z Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins

http://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2253.html Selective, rapid and optically switchable regulation of protein function in live mammalian cells

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