Core histone exchange in the absence of DNA accessibility

In our new bioRxiv preprint, we reveal the surprisingly dynamic nature of interstitial heterochromatin in mouse embryonic stem cells. Interstitial heterochromatin is formed over relatively small (typically 10kb or less) domains harbouring endogenous retroviral elements.

Fundamentally, or results suggest that H3.3 incorporation, and thus exchange of core histones is compatible with the hallmarks of heterochromatin, H3K9me3 and HP1-binding.

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