Laboratory of Chemical and Synthetic Systems Biology

at SciLifeLab Stockholm                                                                                                      Positions available!

Our laboratory develops new synthetic and chemical biology methods to perform ‘biochemistry in the living cell’.  The aim is to understand protein function in a mechanistic and quantitative manner, in the context of the living cell. To perform specific and quantitative biochemical assays in the living cell, two key challenges have to be addressed: first, how can we make accurate and quantitative measurements in the cellular environment?  Second, how can we introduce specific perturbations controlled in space and time? To this end, we are developing tools to engineer proteins in living cells based on genetic code expansion and unnatural amino acid mutagenesis. We aim, for example, to control and probe chromatin proteins using light-activated and bioorthogonal chemistries. These methods, combined with quantitative, high-throughput, proteomic and genomic read-outs, allow us to dissect the complex mechanisms governing cellular processed involved in DNA metabolism, gene regulation, cellular signaling. Having a long-standing interest in chromatin biology, we currently focus on mechanism of chromatin dynamics, histone modifications and epigenetic inheritance. We are studying the function of Polycomb group proteins and their histone marks in setting and maintaining developmental gene expression programs. We are also interested in the molecular underpinnings of pluripotency and mechanism that initiate lineage commitment in early embryonic development. Lastly, we have a separate research program in understanding the role of small proteins and peptides in cells, again relying on our synthetic biology toolbox to elucidate their function in the cellular context.

SHORT NEWS

Congratulations Carmen Navarro, Jing, Anna, Rozina on their paper in Nature Communications

Elsässer lab and Swedish business developers receive an ERC Proof-of-Concept Grant 

Simon Elsässer
is selected for SSF Future Research Leader 7 Program

Congratulations Jing Lyu, Angelo Salazar, Lea van Husen for passing their half-time reviews this spring with flying colors

Welcome thesis students Linus Brinkenstråhle, Hanna SchwämmleMichael Schrempf, Adrià Gassó

Welcome computational PhD student Yuying Cheng

Simon Elsässer
is appointed as Wallenberg Academy Fellow

Lab retreat with team building and strategic sessions at Solvik

Welcome visiting students Maximilian Hornisch (Munich), Jana Braunger (Heidelberg) and Mrinal Panday (KTH)

Dörte Schlesinger
attends the MBL Physiology Course 2019

Simon Elsässer takes up visiting fellowship at Wissenschaftskolleg zu Berlin


Histones win the Lasker Award: Congratulation to David Allis and Michael Grunstein

Welcome summer students Ruth Lappalainen and Laura Neises

Dörte Schlesinger
wins Boehringer Ingelheim Fonds PhD Fellowship

Welcome master and project students Turid Everitt, Alexandra Morscher, Johannes Heimgärtner, Javier Gomez, Sofia Kalaidopoulou, Minh Nguyen Trung

Rui Shao
 is accepted to The Swedish Bioinformatics Advisory Program

Björn Högberg, Ana Texeira, Simon Elsässer receive collaborative Wallenberg Project Grant

Welcome summer and master students Rumeysa Ermis, Franziska Liss, Matthias Block, Kyle Kimler, Marianne Simon, Justine Brun

Computer Scientist Carmen Navarro Luzon joins the lab

Elsässer lab receives Wallenberg Bioinformatics support grant

Dörte Schlesinger joins the lab

Rozina Caridha joins the lab

Lorenzo Lafranchi and Angelo Salazar join the lab

Elsässer lab receives a two collaborative doctoral education grants from KI

Elsässer lab receives a Cancerfonden grant

Simon Elsässer is named a Ragnar Soderberg Fellow in Medicine 2016



Elsässer lab receives a grant from the
The Ming Wai Lau Centre for Reparative Medicine

Rui Shao
joins lab on CSC PhD student scholarhip.

 Philip Yung joins the lab on Croucher Foundation Fellowship

Elsässer lab receives an ERC Starting Grant!!

Welcome summer student Laura Neises

Welcome new students Helena Ishak, Alexander Kühn and Mareike Bach

Thanks for a contribution by the Clas Groschinsky Foundation

Meet Simon at the Bridging Worlds Through Science conference

Congratulations to Maria Pires passing her MSc defense

Welcome new Students Banushree Kumar and Annika Faucon

Congratulations to Evan Alsaleem passing his MSc defense

Welcome new students Lea van Husen, Daniel Horn, Taotao Xiang

Anna-Maria Katsori wins Swedish Childhood Cancer Foundation Postdoc Fellowship

Simon Elsässer receives grant from The Swedish Foundation for International Cooperation in Research and Higher Education for establishing an international collaboration for Alzheimer’s research

Simon Elsässer has been appointed to the Global Young Academy

Elsässerlab receives grant from Åke Wibergs Foundation

 

We are always looking for talented Master, PhD candidates and Postdocs

Please contact us for more information at simon at elsaesserlab.org

Funding from the Strategic Research Programme in Molecular Biosciences (strategiska forskningsområdet Molekylär biovetenskap)

 

 

 

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s